Endocrine Abstracts

Dexamethasone reduces mortality in COVID patients who require oxygen therapy. Dexamethasone-related hyperglycaemia however is a known complication. Capillary blood glucose (CBGs) above 10.0 mmol/l have been linked to increased mortality in COVID patients. Approximately a third of COVID patients with dexamethasone-related hyperglycaemia may develop diabetes later. It is therefore important to manage acute episodes of hyperglycaemia effectively and identify these patients for fo...

Introduction: Here, I present an interesting case of stuttering priapism in a 48 years old man. He was 30 years old when he was diagnosed with this condition. He is being treated with cyproterone acetate with significant improvement in his symptoms.Clinical case: A 30 years old man (now 48) presented to A&E with painful prolonged erection (priapism). He denied any history of trauma, blood disorders, use of recreational drugs, over the counter drugs o...

Introduction: I present here a challenging case of gastrinoma which posed challenges in diagnosis and treatment. Gastrinomas are tumours of pancreas or duodenum secreting excessive gastrin leading to acid over secretion in stomach leading to ulcer, perforations, and diarrhoea.Clinical case: A 77-year-old lady had been suffering from gradually worsening bouts of severe watery diarrhoea and vomiting for previous 10 years and six stones weight loss. Frequen...

Background: I present a young girl with maturity onset diabetes of young type 5 (MODY 5) who presented with renal cysts and early onset bilateral cataracts with gradual decline of beta cell functions.Case: 19 years old girl presented to A&E with hyperglycemia, ketosis, and acidosis. This was her second presentation in A&E in previous 3 weeks. She was diagnosed with type 1 diabetes when she was 3 years old in view of her polyuria and slow growth. ...

Introduction: I present here a patient with congenital adrenal hyperplasia and Fragile X syndrome. The two conditions are rare and not known to be related to each other.Clinical case: A 26-years-old lady was referred to Endocirne clinic with primary amenorrhoea. She complained of hirsutism and some facial acne since 14 years of age. To the best of her recollection her thelarche was around 12 years of age and pubic hair started to appear at 10 years of ag...

Background: Hypercalcaemia in endocrine patients often poses diagnostic challenge, with hyperparathyroidism and familial hypocalciuric-hypercalcaemia(FHH) being common differentials. This case-report presents unique and complex aetiology, underscoring need for comprehensive evaluation.Case-Description: We present case of 57-year-old Caucasian-woman referred to our clinic with persistently elevated calcium and parathyroid...

Case history: A 51-year old female presented to emergency with occipital headache for 5 days on a background of recurrent headaches for over a year. She had been diagnosed with Hashimoto’s disease at the age of 30 and given levothyroxine, which she discontinued 5 years ago due to aversion to take medications. She had noticed cold intolerance and low energy. At presentation her body mass index was 25.26 kg/m2 and the physical exam was unremarkable; specifically,...

Case history: A 29-year-old man presented with infertility. He also complained of difficulty in passing urine. He also complained of low libido and ejaculate was also noted to be watery. He complained of occasional difficulty in maintaining erections. He denied history of trauma, radiation exposure or use of illicit drugs. He had normal pubertal development and secondary sexual features. He had undergone a surgery about 11 years ago in Nigeria for hypospadias. Hypospadias was ...

A 52 year old man presented 5 years ago with a history of persistent rhinorrhea, blocked nose and epistaxis. MR scanning revealed blockage of the ethmoid sinus with polypoidal material extending into the nasopharynx, anterior cranial fossa and right orbit. He had craniofacial resection of the lesion and histology confirmed an olfactory neuroblastoma.He represented in 2005 with a two-week history of generalized weakness, lack of energy, and bilateral ankl...

Background: There are nearly 5 million people with diabetes mellitus in the UK with an estimated 10% of diabetes patients developing a foot ulcer at some point in their lives. Nearly 9500 diabetes-related amputations are reported in the UK per year and approximately 80% of the NHS budget on diabetes care is spent on treating complications. Limb/life-threatening diabetic foot problems are referred to acute services immediately and all other active diabetic foot diseases are ref...